Glycopeptide antibiotic analogs for selective inactivation and two-photon imaging of vancomycin-resistant strains.

نویسندگان

  • Shinya Ariyasu
  • Pei Chui Too
  • Jing Mu
  • Chi Ching Goh
  • Yichen Ding
  • Ya Lin Tnay
  • Edwin Kok Lee Yeow
  • Liang Yang
  • Lai Guan Ng
  • Shunsuke Chiba
  • Bengang Xing
چکیده

A novel theranostic divalent vancomycin analog using a planar 1,8-diazapyrene moiety as a rigid scaffold exhibits potent and selective antibacterial activity against Gram (+) bacteria including vancomycin-resistant strains, while having minimal influence on Gram (-) bacteria and mammalian cells. Moreover, this theranostic analog can be also applied for selective two-photon fluorescence imaging of Gram (+) bacteria.

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عنوان ژورنال:
  • Chemical communications

دوره 52 25  شماره 

صفحات  -

تاریخ انتشار 2016